两个成瘾机制的细节介绍(多巴胺和谷氨酸通路;成瘾可能性公式和成瘾周期表)

dopamine & glutamate

形象爆了。这是我看到最有趣的讲解dopamine和glutamate而且深入度还好的视频。

(才发现glutamate是“谷氨酸”,氨基酸之一,很常见没想到在奖赏机制和行为选择里面的作用这么重要啊!(土鳖表示很惭愧))

 

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periodic table of drugs 毒品的周期表,考虑了针对奖励中枢的不同作用来进行的区分,比那个只考虑半衰期/欣快程度/欣快时间来判断成瘾容易度的等式要有道理得多。不过这个周期表不知道同行评价怎样。

(有些细节没听懂,不过整体很有道理)

 

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成瘾容易度的公式(algebraic equation)  A = E/T max  t 1/2 ,

A is the addictive potency,成瘾倾向
E represents the euphoric potency,欣快可能
T max is the time to reach peak plasma concentration, 快感时间
t 1/2 is the plasma elimination half-life,毒品的半衰期

Salerian, A.J. (2010). Addictive potential :Addictive potential: A = E/T max  t 1/2     Medical Hypotheses 74 (2010) 1081–1083

 

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